Recombinant DNA (rDNA) is a form of artificial DNA
that is created by combining two or more sequences that would not normally
occur together.
In terms of genetic modification, it is created
through the introduction of relevant DNA into an existing organismal DNA, such
as the plasmids of bacteria, to code for or alter different traits for a
specific purpose, such as antibiotic resistance.
It differs from genetic recombination in that it does
not occur through natural processes within the cell, but is engineered.
The recombinant DNA technique was first proposed by
Peter Lobban, a graduate student, with A. Dale Kaiser at the Stanford University
Department of Biochemistry.
The technique was then realized by Lobban and Kaiser;
Jackson, Symons and Berg; and Stanley Norman Cohen, Chang, Herbert Boyer and
Helling, in 1972–74.
Fig. Shows how a Recombinant DNA molecule is form
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